Telomere attrition and decreased Fetuin-A levels indicate accelerated biological ageing and are implicated in the pathogenesis of Colorectal Cancer Maxwell
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چکیده
Purpose Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of ageing and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and ageing process could prove useful in this regard.
منابع مشابه
Human Cancer Biology Telomere Attrition and Decreased Fetuin-A Levels Indicate Accelerated Biological Aging and Are Implicated in the Pathogenesis of Colorectal Cancer
Purpose: Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and aging process could prove useful in this
متن کاملTelomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the pathogenesis of colorectal cancer.
PURPOSE Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. The role of telomere biology in both the cancer and aging process could prove useful in this regard. EXPERIMENTAL DESIGN Using quantitative PCR, we determined telomere length in...
متن کاملAccelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort
BACKGROUND It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional and novel risk factors, with biological-ageing, as measured by telomere length, in a Glasgow based cohort that included individuals with ...
متن کاملPhysiology of Plants Affected by Ageing
Objective: Ageing of the stored seed is a natural phenomenon and the seeds tend to lose viability even under ideal storage conditions. Accelerated ageing has been recognized as a good predictor of the storability of seed lots. Aged seeds show decreased vigor and produce weak seedlings that are unable to survive once reintroduced into a habitat. The characteristics of the chemical composition of...
متن کاملPhysiology of Plants Affected by Ageing
Objective: Ageing of the stored seed is a natural phenomenon and the seeds tend to lose viability even under ideal storage conditions. Accelerated ageing has been recognized as a good predictor of the storability of seed lots. Aged seeds show decreased vigor and produce weak seedlings that are unable to survive once reintroduced into a habitat. The characteristics of the chemical composition of...
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تاریخ انتشار 2011